Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana

Fitoterapia. 2022 Jun:159:105175. doi: 10.1016/j.fitote.2022.105175. Epub 2022 Mar 13.

Abstract

Four new isoquinoline alkaloids including a benzophenanthridine alkaloid (1), a morphine derivative (2), a narceine-type alkaloid (3) and a simple isoquinoline alkaloid (4), a new amide alkaloid (5) and a new phthalic acid derivative (6), together with eleven known alkaloids (7-17) were obtained from the whole herbs extract of Corydalis bungeana Turcz. Their structures and absolute configurations were elucidated by extensive spectroscopic data analysis including HRESIMS, NMR and electronic circular dichroism (ECD) and ECD calculation. Compounds 1-17 were evaluated for dopamine D2 receptor activity in CHO-D2 cells. Among them, 16 showed the highest antagonistic activity on the D2 receptor with an IC50 value of 2.04 ± 0.01 μM. Compounds 14 and 15 exhibited moderate antagonism with IC50 values of 13.66 ± 2.28 and 31.72 ± 2.52 μM, respectively.

Keywords: Amide alkaloid; Corydalis bungeana; D2 receptor activity; Isoquinoline alkaloids; Papaveraceae.

MeSH terms

  • Alkaloids* / chemistry
  • Alkaloids* / pharmacology
  • Amides
  • Corydalis* / chemistry
  • Dopamine D2 Receptor Antagonists
  • Isoquinolines / chemistry
  • Isoquinolines / pharmacology
  • Molecular Structure
  • Receptors, Dopamine D2

Substances

  • Alkaloids
  • Amides
  • Dopamine D2 Receptor Antagonists
  • Isoquinolines
  • Receptors, Dopamine D2