BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis

Ko Kudo; Tsutomu Toki; Rika Kanezaki; Tatsuhiko Tanaka; Takuya Kamio; Tomohiko Sato; Shinya Sasaki; Masaru Imamura; Chihaya Imai; Kumiko Ando; Harumi Kakuda; Takehiko Doi; Hiroshi Kawaguchi; Masahiro Irie; Yoji Sasahara; Akihiro Tamura; Daiichiro Hasegawa; Yosuke Itakura; Kenichiro Watanabe; Kenichi Sakamoto; Yoko Shioda; Motohiro Kato; Kazuko Kudo; Reiji Fukano; Atsushi Sato; Hiroshi Yagasaki; Hirokazu Kanegane; Itaru Kato; Katsutsugu Umeda; Souichi Adachi; Tatsuki Kataoka; Akira Kurose; Atsuko Nakazawa; Kiminori Terui; Etsuro Ito

doi:10.3324/haematol.2021.279857

BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis

Haematologica. 2022 Jul 1;107(7):1719-1725. doi: 10.3324/haematol.2021.279857.

Authors

Ko Kudo¹, Tsutomu Toki², Rika Kanezaki², Tatsuhiko Tanaka², Takuya Kamio², Tomohiko Sato², Shinya Sasaki², Masaru Imamura³, Chihaya Imai³, Kumiko Ando⁴, Harumi Kakuda⁴, Takehiko Doi⁵, Hiroshi Kawaguchi⁵, Masahiro Irie⁶, Yoji Sasahara⁶, Akihiro Tamura⁷, Daiichiro Hasegawa⁷, Yosuke Itakura⁸, Kenichiro Watanabe⁸, Kenichi Sakamoto⁹, Yoko Shioda⁹, Motohiro Kato¹⁰, Kazuko Kudo¹¹, Reiji Fukano¹², Atsushi Sato¹³, Hiroshi Yagasaki¹⁴, Hirokazu Kanegane¹⁵, Itaru Kato¹⁶, Katsutsugu Umeda¹⁶, Souichi Adachi¹⁷, Tatsuki Kataoka¹⁸, Akira Kurose¹⁹, Atsuko Nakazawa²⁰, Kiminori Terui², Etsuro Ito²¹

Affiliations

¹ Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki. kkudo@hirosaki-u.ac.jp.
² Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki.
³ Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata.
⁴ Department of Hematology and Oncology, Chiba Children's Hospital, Chiba.
⁵ Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima.
⁶ Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai.
⁷ Department of Hematology and Oncology, Children's Cancer Center, Hyogo Prefectural Kobe Children's Hospital, Kobe.
⁸ Department of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka.
⁹ Children's Cancer Center, National Center for Child Health and Development, Tokyo.
¹⁰ Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo.
¹¹ Department of Pediatrics, Fujita Health University School of Medicine, Aichi.
¹² Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi.
¹³ Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai.
¹⁴ Department of Pediatrics, Nihon University Graduate School of Medicine, Tokyo.
¹⁵ Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo.
¹⁶ Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto.
¹⁷ Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto.
¹⁸ Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Pathology, Iwate Medical University, Iwate.
¹⁹ Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki.
²⁰ Department of Clinical Research, Saitama Children's Medical Center, Saitama.
²¹ Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Department of Community Medicine, Hirosaki University Graduate School of Medicine, Hirosaki. eturou@hirosaki-u.ac.jp.

No abstract available

MeSH terms

Biomarkers
Bone Marrow Diseases*
Child
Histiocytosis, Langerhans-Cell* / diagnosis
Histiocytosis, Langerhans-Cell* / genetics
Humans
Mutation
Proto-Oncogene Proteins B-raf / genetics

Substances

Biomarkers
BRAF protein, human
Proto-Oncogene Proteins B-raf

Grants and funding

Funding: This study was partially supported by the Japan Society for the Promotion of Science through a Grant-in-Aid for Scientific Research (KAKENHI: 17K10095, 21K07813) and Japan Cancer Research Project 21ck0106605h0002 from the Japan Agency for Medical Research and Development (AMED).