Construction and verification of an infectious cDNA clone of coxsackievirus B5

Virol Sin. 2022 Jun;37(3):469-471. doi: 10.1016/j.virs.2022.03.005. Epub 2022 Mar 11.

Authors

Affiliations

¹ National Institute for Food and Drug Control, Beijing 102629, China.
² National Institute for Food and Drug Control, Beijing 102629, China; Wuhan Institute of Biological Products CO., LTD, Wuhan 430070, China.
³ National Institute for Food and Drug Control, Beijing 102629, China. Electronic address: maoqunying@126.com.
⁴ National Institute for Food and Drug Control, Beijing 102629, China. Electronic address: lzhenglun@126.com.

Abstract

•
An infectious cDNA clone of CV-B5 was constructed.
•
The rescued and parental virus possessed similar biological characteristics.
•
The virulence of the rescued virus was similiar to that of the parental virus.
•
Viral distribution and tissue tropism of those two viruses were in agreement.

Publication types

Letter

MeSH terms

Clone Cells
Cloning, Molecular
Coxsackievirus Infections*
DNA, Complementary / genetics
Enterovirus B, Human* / genetics
Humans

Substances

DNA, Complementary