Targeting tumor associated macrophages in hepatocellular carcinoma

Wenqian Xu; Yuliang Cheng; Yahui Guo; Weirong Yao; He Qian

doi:10.1016/j.bcp.2022.114990

Targeting tumor associated macrophages in hepatocellular carcinoma

Biochem Pharmacol. 2022 May:199:114990. doi: 10.1016/j.bcp.2022.114990. Epub 2022 Mar 11.

Authors

Wenqian Xu¹, Yuliang Cheng¹, Yahui Guo¹, Weirong Yao², He Qian³

Affiliations

¹ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China.
² School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
³ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. Electronic address: qianhe@jiangnan.edu.cn.

PMID: 35288152
DOI: 10.1016/j.bcp.2022.114990

Abstract

Hepatocellular carcinoma (HCC) contains numerous immune cell stroma, which constitutes the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) represent the major compartment of immune cell stroma of HCC and play an important role in HCC pathogenesis, involving in immunosuppressive, angiogenesis, tumor invasion and metastasis, metabolic support, drug resistance, and HCC stem cells malignant transformation. Current targeting TAMs to treat HCC have been achieved a promising therapeutic outcome by eliminating TAMs present, blocking recruitment of TAMs, reprogramming TAMs polarization, modulating TAMs products and restoring TAMs phagocytic capacity. This review summarizes what we have known on TAMs and HCC, discussing the roles of TAMs in HCC development and the possible approaches for TAMs-targeted therapy as potential targets for HCC treatment.

Keywords: Hepatocellular carcinoma; Mechanisms; Therapy; Tumor microenvironment; Tumor-associated macrophages.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular* / metabolism
Humans
Liver Neoplasms* / drug therapy
Macrophages / metabolism
Tumor Microenvironment
Tumor-Associated Macrophages