Effects of Plant Extracts on Dentin Bonding Strength: A Systematic Review and Meta-Analysis

Shikai Zhao; Fang Hua; Jiarong Yan; Hongye Yang; Cui Huang

doi:10.3389/fbioe.2022.836042

Effects of Plant Extracts on Dentin Bonding Strength: A Systematic Review and Meta-Analysis

Front Bioeng Biotechnol. 2022 Feb 24:10:836042. doi: 10.3389/fbioe.2022.836042. eCollection 2022.

Authors

Shikai Zhao¹, Fang Hua^{2

3}, Jiarong Yan¹, Hongye Yang^{1

4}, Cui Huang^{1

4}

Affiliations

¹ The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
² Department of Orthodontics, Center for Evidence-Based Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
³ Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
⁴ Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Abstract

Objective: To systematically review in vitro studies that evaluated the effects of plant extracts on dentin bonding strength. Materials and Methods: Six electronic databases (PubMed, Embase, VIP, CNKI, Wanfang and The Cochrane Library) were searched from inception to September 2021 in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA). In vitro studies that compared the performance of dental adhesives with and without the plant extracts participation were included. The reference lists of the included studies were manually searched. Two researchers carried out study screening, data extraction and risk of bias assessment, independently and in duplicate. Meta-analysis was conducted using Review Manager 5.3. Results: A total of 62 studies were selected for full-text analysis. 25 articles used the plant extracts as primers, while five added the plant extracts into adhesives. The meta-analysis included 14 articles of in vitro studies investigating the effects of different plant extract primers on dentin bonding strength of etch-and-rinse and self-etch adhesives, respectively. The global analysis showed statistically significant difference between dental adhesives with and without plant extract primers. It showed that the immediate bond strength of dental adhesives was improved with the application of plant extract primers. Conclusion: The application of proanthocyanidin (PA) primers have positive effect on the in vitro immediate bonding strength of dental adhesives irrespective of etch-and-rinse or self-etch modes.

Keywords: adhesives; bonding; dentin; natural crosslinkers; plant extracts; primers.

Publication types

Review