Salzmann nodular degeneration in posterior keratoconus: a case report

BMC Ophthalmol. 2022 Mar 12;22(1):117. doi: 10.1186/s12886-022-02268-3.

Abstract

Background: To report an unusual case of salzmann nodular degeneration (SND) in posterior keratoconus (PKC) after a corneal penetrating injury.

Case presentation: A 56-year-old woman presented with a history of recurrent light sensitivity, foreign body sensation, and tears after a corneal penetrating injury 20 years ago. The patient was diagnosed with SND accompanying with PKC by slit-lamp microscope, anterior segment optical coherence tomography (OCT), and corneal tomography. A combined therapy of medication (0.1% sodium hyaluronate eye drops, recombinant bovine basic fibroblast growth factor eye drops, and 0.1% fluorometholone eye drops) and bandage contact lens could not relieve the latest episode. A phototherapeutic keratectomy (PTK) treatment (laser ablation depth: 15 μm; treatment zone: 7.5 mm) was performed to remove nodules and smooth the surface. The best spectacle-corrected visual acuity improved from 20/63 preoperatively to 20/40 postoperatively. No SND relapse and corneal ectasia were recorded at follow-up 12 months later.

Conclusions: This is the first known, reported case of SND accompanying with PKC after corneal trauma. The PTK is a safe and effective option for SND with PKC.

Keywords: Phototherapeutic keratectomy; Posterior keratoconus; Salzmann nodular degeneration.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Cattle
  • Corneal Topography
  • Female
  • Humans
  • Keratoconus* / complications
  • Keratoconus* / drug therapy
  • Lasers, Excimer / therapeutic use
  • Middle Aged
  • Photorefractive Keratectomy* / methods
  • Visual Acuity