Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Hongwon Kim; Jaein Shin; Sumin Kim; Siyoung Kim; Byounggook Cho; Sang-Jun Park; Gwoncheol Park; Hakdong Shin; Myeong Soo Park; Jongpil Kim

doi:10.1016/j.bbrc.2022.03.024

Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Biochem Biophys Res Commun. 2022 May 7:603:41-48. doi: 10.1016/j.bbrc.2022.03.024. Epub 2022 Mar 5.

Authors

Affiliations

¹ Laboratory of Stem Cells & Cell Reprogramming, Department of Biomedical Engineering, Dongguk University, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, Republic of Korea; Department of Chemistry, Dongguk University, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, Republic of Korea.
² Department of Chemistry, Dongguk University, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, Republic of Korea.
³ Research Center, BIFIDO Co, Ltd, Hongcheon, Kangwon, 25117, Republic of Korea.
⁴ Department of Food Science and Biotechnology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 05006, Republic of Korea.
⁵ Research Center, BIFIDO Co, Ltd, Hongcheon, Kangwon, 25117, Republic of Korea. Electronic address: bifidopark@bifido.com.
⁶ Laboratory of Stem Cells & Cell Reprogramming, Department of Biomedical Engineering, Dongguk University, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, Republic of Korea; Department of Chemistry, Dongguk University, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, Republic of Korea. Electronic address: jk2316@gmail.com.

PMID: 35278878
DOI: 10.1016/j.bbrc.2022.03.024

Abstract

An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

Keywords: Aging; Bifidobacterium; Cognitive and memory impairment; Gut microbiota; Probiotics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bifidobacterium bifidum* / genetics
Bifidobacterium longum*
Gastrointestinal Microbiome*
Mice
Probiotics*
Rejuvenation