Two cases of resected gallbladder carcinosarcoma with a contrasting course

Toru Kato; Yasutoshi Kimura; Tomohiro Kubo; Ayako Murota; Tadashi Hasegawa; Ichiro Takemasa

doi:10.1016/j.ijscr.2022.106915

Two cases of resected gallbladder carcinosarcoma with a contrasting course

Int J Surg Case Rep. 2022 Mar:92:106915. doi: 10.1016/j.ijscr.2022.106915. Epub 2022 Mar 4.

Authors

Toru Kato¹, Yasutoshi Kimura², Tomohiro Kubo³, Ayako Murota⁴, Tadashi Hasegawa⁵, Ichiro Takemasa⁶

Affiliations

¹ Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, S1 W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Electronic address: toru.kato1969@gmail.com.
² Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, S1 W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Electronic address: kimuray@sapmed.ac.jp.
³ Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, S1 W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Electronic address: kubotomo@sapmed.ac.jp.
⁴ Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, S1 W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Electronic address: iiiiiaaaaayako@gmail.com.
⁵ Department of Surgical Pathology, Sapporo Medical University School of Medicine, S1 W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Electronic address: t.hasegawa@sapmed.ac.jp.
⁶ Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, S1 W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Electronic address: itakemasa@sapmed.ac.jp.

Abstract

Introduction: Carcinosarcoma of the gallbladder is a rare tumor with both carcinoma and sarcoma components.

Case presentation: In this paper, we report two cases. The first case is of a man in his 60s who was preoperatively diagnosed with gallbladder carcinosarcoma and has achieved 6 years and 6 months survival through aggressive surgical treatment. The second case is of a woman in her 70s who was diagnosed with locally advanced gallbladder cancer; she underwent multidisciplinary treatment for the same, but died 8 months after the surgery. While the primary disorder was the same in both cases, the clinical courses contrasted sharply.

Discussion: There is no established chemotherapy or radiation therapy for gallbladder carcinosarcoma, and the only curative treatment is surgery. However, it has a very poor prognosis.

Conclusion: Carcinosarcoma of the gallbladder may progress very rapidly, and the treatment management should be carefully decided.

Keywords: Carcinosarcoma; Gallbladder; Multidisciplinary therapy; Surgical resection.