Modelling SPECT auto-contouring acquisitions for 177Lu & 131I molecular radiotherapy using new developments in Geant4/GATE

Abstract

Purpose: Monte Carlo modelling of SPECT imaging in Molecular Radiotherapy can improve activity quantification. Until now, SPECT modelling with GATE only considered circular orbit (CO) acquisitions. This cannot reproduce auto-contour acquisitions, where the detector head moves close to the patient to improve image resolution. The aim of this work is to develop and validate an auto-contouring step-and-shoot acquisition mode for GATE SPECT modelling.

Methods: ¹⁷⁷Lu and ¹³¹I SPECT experimental acquisitions performed on a Siemens Symbia T2 and GE Discovery 670 gamma camera, respectively, were modelled. SPECT projections were obtained for a cylindrical Jaszczak phantom and a lung and spine phantom. Detector head parameters (radial positions and acquisition angles) were extracted from the experimental projections to model the non-circular orbit (NCO) detector motion. The gamma camera model was validated against the experimental projections obtained with the cylindrical Jaszczak (¹⁷⁷Lu) and lung and spine phantom (¹³¹I). Then, ¹⁷⁷Lu and ¹³¹I CO and NCO SPECT projections were simulated to validate the impact of explicit NCO modelling on simulated projections.

Results: Experimental and simulated SPECT images were compared using the gamma index, and were in good agreement with gamma index passing rate (GIPR) and gamma_avg of 96.27%, 0.242 (¹⁷⁷Lu) and 92.89%, 0.36 (¹³¹I). Then, simulated ¹⁷⁷Lu and ¹³¹I CO and NCO SPECT projections were compared. The GIPR, gamma_avg between the two gamma camera motions was 99.85%, 0.108 for ¹⁷⁷Lu and 75.58%, 0.6 for ¹³¹I.

Conclusion: This work thereby justifies the need for auto-contouring modelling for isotopes with high septal penetration.

Keywords: Auto-contouring; GATE Monte Carlo modelling; SPECT imaging; Tessellation.