Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin

Cureus. 2022 Feb 3;14(2):e21884. doi: 10.7759/cureus.21884. eCollection 2022 Feb.

Abstract

We formerly reported that the combination of dichloroacetate, omeprazole, and tamoxifen blocked cancer progression by reducing lactic acid production and inducing superoxide production. Recently, ivermectin, a well-known anti-parasite drug, was reported to share the same mechanisms with them and have anti-tumor activity. Here, we present three patients in whom the combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin dramatically relieved the symptoms accompanying cancer and sarcoma progression.

Keywords: cancer; dichloroacetate; ivermectin; omeprazole; sarcoma; tamoxifen.

Publication types

  • Case Reports