Abstract
Invasion and metastasis is the hallmark of tumour malignancy. Some aspects of invasion and metastasis with potential implications for tumour therapy are reviewed: the value of laboratory models; the acquisition of invasiveness and metastatic capability during carcinogenesis; the relationship between growth and invasion; clinical and experimental anti-invasive and antimetastatic agents. The value of joint experimental and clinical research is underscored.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antibodies, Monoclonal / therapeutic use
-
Chick Embryo
-
Female
-
Flavonoids / therapeutic use
-
Humans
-
Laminin / physiology
-
Mice
-
Microtubules / drug effects
-
Microtubules / pathology
-
Neoplasm Invasiveness*
-
Neoplasm Metastasis* / pathology
-
Neoplasm Metastasis* / prevention & control
-
Neoplasm Metastasis* / therapy
-
Neoplasms / drug therapy
-
Neoplasms / etiology
-
Neoplasms / genetics
-
Neoplasms / pathology
-
Neoplasms / therapy*
-
Neoplasms, Experimental / genetics
-
Neoplasms, Experimental / pathology
-
Neoplasms, Experimental / therapy
-
Oncogenes
-
Plasminogen Activators / physiology
-
Rats
Substances
-
Antibodies, Monoclonal
-
Flavonoids
-
Laminin
-
Plasminogen Activators