Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition

Affiliations

• ¹ Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Munich, 81675, Germany.
• ² Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, 12203, Germany.
• ³ Institute of Medical Psychology and Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, 80336, Germany.
• ⁴ Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technical University Munich, Munich, 81675, Germany.
• ⁵ Department of Toxicology, University of Mainz Medical Center, Mainz, 55131, Germany.
• ⁶ German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, 69120, Germany.
• ⁷ Center for Protein Assemblies (CPA), Technical University of Munich, Garching, 85747, Germany.
• ⁸ Institute for Translational Cancer Research and Experimental Cancer Therapy, Technical University Munich, Munich, 81675, Germany.
• ⁹ Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, 37075, Germany.