Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF

Reza Akhavan-Sigari; Malihe Zeraati; Mohammadreza Moghaddam-Manesh; Parya Kazemzadeh; Sara Hosseinzadegan; Narendra Pal Singh Chauhan; Ghasem Sargazi

doi:10.1186/s13065-022-00804-2

Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF

BMC Chem. 2022 Mar 5;16(1):10. doi: 10.1186/s13065-022-00804-2.

Authors

Reza Akhavan-Sigari¹, Malihe Zeraati², Mohammadreza Moghaddam-Manesh³, Parya Kazemzadeh⁴, Sara Hosseinzadegan⁵, Narendra Pal Singh Chauhan⁶, Ghasem Sargazi⁷

Affiliations

¹ Department of Neurosurgery, University of Nebraska Medical Center, Tuebingen, Germany.
² Department of Materials Engineering, Shahid Bahonar University of Kerman, 761694111, Kerman, Iran.
³ Petrochemistry and Polymer Research Group, Chemistry and Petrochemistry Research Center, Standard Research Institute, Tehran, Iran.
⁴ Department of Chemistry, Lorestan University, Khorramabad, Iran.
⁵ Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.
⁶ Department of Chemistry, Faculty of Science, Bhupal Nobles' University, Udaipur, Rajasthan, India.
⁷ Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. g.sargazi@gmail.com.

Abstract

The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO₃)₂·3H₂O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nitrogen adsorption analysis, SEM and TEM-EDX. The morphology of Cu-MOFs was spherical, with an average particle size distribution of less than 100 nm. Using BET analysis, the surface area of Cu-MOF was found to be 284.94 m²/g. The porous morphology of Cu-MOF was also suggested by SEM and TEM analyses. It has anticancer properties against MCF-7 breast cancer cells. Cytotoxicity testing was performed on MCF-7 breast cancer cells using the MTT cell viability assay, and cell proliferation and viability were found to be approximately 24% higher than the control.

Keywords: Anticancer; Cell viability; Characterization; Cu-MOF.