Revisiting Intracavitary Immunotherapy of Cancer

Clin Cancer Res. 2022 May 13;28(10):1993-1995. doi: 10.1158/1078-0432.CCR-22-0201.

Abstract

Ovarian cancer is often limited to the peritoneal cavity in the form of peritoneal carcinomatosis. Peritoneal spreading offers the opportunity for locoregional delivery of combinations of immunotherapy agents, maximizing bioavailability while potentially reducing systemic exposure and side effects. See related article by Orr et al., p. 2038.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Carcinoma, Ovarian Epithelial
  • Chemokines
  • Female
  • Humans
  • Immunotherapy / adverse effects
  • Ligands
  • Ovarian Neoplasms* / drug therapy
  • Peritoneal Neoplasms* / drug therapy
  • Receptors, CXCR3

Substances

  • CXCR3 protein, human
  • Chemokines
  • Ligands
  • Receptors, CXCR3