A genetic TRP down the channel to praziquantel resistance

Trends Parasitol. 2022 May;38(5):351-352. doi: 10.1016/j.pt.2022.02.006. Epub 2022 Mar 1.

Abstract

The anthelmintic praziquantel (PZQ) is an essential tool in controlling schistosomiasis, so reports of reduced PZQ efficacy are of great public health concern. Le Clec'h et al. recently identified a gene responsible for PZQ resistance in experimentally selected resistant Schistosoma mansoni. The importance of this locus in natural infections remains to be established.

Keywords: Schistosoma mansoni; praziquantel; resistance; transient receptor potential channel.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Anthelmintics* / pharmacology
  • Anthelmintics* / therapeutic use
  • Drug Resistance / genetics
  • Praziquantel / pharmacology
  • Praziquantel / therapeutic use
  • Schistosoma mansoni / genetics
  • Schistosomiasis mansoni* / drug therapy

Substances

  • Anthelmintics
  • Praziquantel