Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Li-Na Miao; Deng Pan; Junhe Shi; Jian-Peng Du; Peng-Fei Chen; Jie Gao; Yanqiao Yu; Da-Zhuo Shi; Ming Guo

doi:10.3389/fcvm.2022.816369

Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Front Cardiovasc Med. 2022 Feb 15:9:816369. doi: 10.3389/fcvm.2022.816369. eCollection 2022.

Authors

Li-Na Miao^{1

2}, Deng Pan^{1

2}, Junhe Shi¹, Jian-Peng Du^{1

3}, Peng-Fei Chen¹, Jie Gao^{1

3}, Yanqiao Yu^{1

2}, Da-Zhuo Shi^{1

3}, Ming Guo^{1

3}

Affiliations

¹ Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
² Department of Graduate School, Beijing University of Chinese Medicine, Beijing, China.
³ China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Abstract

Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-δ, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-δ in cardiovascular diseases.

Keywords: PKC; PKC-δ; cardiovascular disease; kinase; mechanism.

Publication types

Review