The Research Progress in Physiological and Pathological Functions of TRAF4

Xueqin Ruan; Rong Zhang; Ruijuan Li; Hongkai Zhu; Zhihua Wang; Canfei Wang; Zhao Cheng; Hongling Peng

doi:10.3389/fonc.2022.842072

The Research Progress in Physiological and Pathological Functions of TRAF4

Front Oncol. 2022 Feb 15:12:842072. doi: 10.3389/fonc.2022.842072. eCollection 2022.

Authors

Xueqin Ruan^{1

2}, Rong Zhang³, Ruijuan Li^{1

2}, Hongkai Zhu^{1

2}, Zhihua Wang^{1

2}, Canfei Wang^{1

2}, Zhao Cheng^{1

2}, Hongling Peng^{1

2

4}

Affiliations

¹ Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.
² Institute of Molecular Hematology, Central South University, Changsha, China.
³ Division of Cancer Immunotherapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Chiba, Japan.
⁴ Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Abstract

Tumour necrosis factor receptor-associated factor 4 (TRAF4) is a member of the TRAF protein family, a cytoplasmic bridging molecule closely associated with various immune functions. The physiological processes of TRAF4 are mainly involved in embryonic development, cell polarity, cell proliferation, apoptosis, regulation of reactive oxygen species production. TRAF4 is overexpressed in a variety of tumors and regulates the formation and development of a variety of tumors. In this review, we summarize the physiological and pathological regulatory functions of TRAF4 and focus on understanding the biological processes involved in this gene, to provide a reference for further studies on the role of this gene in tumorigenesis and development.

Keywords: TRAF4; apoptosis; carcinogenesis; pathological; proliferation.

Publication types

Review