Macrophages and Metabolic Reprograming in the Tumor Microenvironment

Jin Liu; Mingwei Gao; Zhou Yang; Yidan Zhao; Kun Guo; Binwen Sun; Zhenming Gao; Liming Wang

doi:10.3389/fonc.2022.795159

Macrophages and Metabolic Reprograming in the Tumor Microenvironment

Front Oncol. 2022 Feb 15:12:795159. doi: 10.3389/fonc.2022.795159. eCollection 2022.

Authors

Jin Liu^{1

2

3}, Mingwei Gao³, Zhou Yang¹, Yidan Zhao², Kun Guo^{1

2}, Binwen Sun^{1

2}, Zhenming Gao^{1

2

3}, Liming Wang^{1

2

3}

Affiliations

¹ Engineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, Dalian Medical University, Dalian, China.
² Engineering Technology Research Center for Translational Medicine, Dalian Medical University, Dalian, China.
³ Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Abstract

Due to the emergence of traditional drug resistance in tumor treatment, the anti-cancer therapies are facing multiple challenges. Immunotherapy, as a new and universal treatment, has been gradually concerned. The macrophages, as an important part of the immune system, play an important role in it. Many studies have shown that immune state is essential in cancer progression and prognosis, rebuilding the architecture and functional orientation of the tumor region. Most tumors are complex ecosystems that change temporally and spatially under the pressure of proliferation, apoptosis, and extension of every cell in the microenvironment. Here, we review how macrophages states can be dynamically altered in different metabolic states and we also focus on the formation of immune exhaustion. Finally, we look forward to the explorations of clinical treatment for immune metabolism process.

Keywords: immunology; intervention; macrophages; metabolic stress; tumor-promotion.

Publication types

Review