Carotid intima-media thickness measurements in patients with multiple sclerosis

Marjan Rahimi Farzan; Sara Esmaeili; Zahra Mirzaasgari; Negin Mahmoudi Hamidabad; Seyedeh Niloufar Rafiei Alavi; Mohammad Taghi Joghataei; Mohammad Reza Motamed

doi:10.1016/j.amsu.2022.103348

Carotid intima-media thickness measurements in patients with multiple sclerosis

Ann Med Surg (Lond). 2022 Feb 9:75:103348. doi: 10.1016/j.amsu.2022.103348. eCollection 2022 Mar.

Authors

Marjan Rahimi Farzan^{1

2}, Sara Esmaeili^{1

2

3

4}, Zahra Mirzaasgari^{1

2}, Negin Mahmoudi Hamidabad^{1

2}, Seyedeh Niloufar Rafiei Alavi⁵, Mohammad Taghi Joghataei^{3

4}, Mohammad Reza Motamed^{1

2}

Affiliations

¹ Firoozgar Clinical Research and Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran.
² Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
³ Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
⁴ School of Advanced Technologies in Medicine, Iran University of Medical, Tehran, Iran.
⁵ Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Objectives: The goal of this study was to evaluate the mean carotid intima-media thickness (CIMT) in patients with Multiple Sclerosis (MS).

Methods: In this cross-sectional study, 100 patients with MS were enrolled. Carotid intima-media thickness was measured by Doppler Ultrasonography. The mean CIMT was then compared between different groups of sex, age, body mass index (BMI), medications, and site of the MS plaques in the brain and cervical MRI. In addition, disease duration, annual relapse rate, and Expanded Disability Status Scale (EDSS) were compared between high and normal CIMT groups.

Results: Among 100 patients, Sixty-two percent of the patients were female. The mean age was 35.95 ± 9.32 years. Mean CIMT was 0.38 ± 0.2 mm, and 22% of the patients had abnormal CIMT measures. CIMT was significantly associated with higher age (P = 0.01) and prolonged disease duration (P < 0.001). CIMT was not associated with other disease factors or types of the disease-modifying drug (P > 0.05).

Conclusion: Multiple Sclerosis might be associated with carotid atherosclerotic vascular disease.

Keywords: Atherosclerosis; Carotid intima-media thickness; Multiple sclerosis.