The Molecular Pathways of Pyroptosis in Atherosclerosis

Dan Song; Manman Li; Xue Yu; Yuqin Wang; Jiaying Fan; Wei Yang; Liming Yang; Hong Li

doi:10.3389/fcell.2022.824165

The Molecular Pathways of Pyroptosis in Atherosclerosis

Front Cell Dev Biol. 2022 Feb 14:10:824165. doi: 10.3389/fcell.2022.824165. eCollection 2022.

Authors

Dan Song¹, Manman Li¹, Xue Yu¹, Yuqin Wang¹, Jiaying Fan¹, Wei Yang¹, Liming Yang², Hong Li¹

Affiliations

¹ Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
² Department of Pathophysiology, Harbin Medical University-Daqing, Daqing, China.

Abstract

Atherosclerosis (AS) is a chronic inflammatory disease seriously endangering human health, whose occurrence and development is related to many factors. Pyroptosis is a recently identified novel programmed cell death associated with an inflammatory response and involved in the formation and progression of AS by activating different signaling pathways. Protein modifications of the sirtuin family and microRNAs (miRNAs) can directly or indirectly affect pyroptosis-related molecules. It is important to link atherosclerosis, thermogenesis and molecular modifications. This article will systematically review the molecular pathways of pyroptosis in AS, which can provide a new perspective for AS prevention and treatment.

Keywords: AMPK; MAPK; NF-κB; SIRT; atherosclerosis; miRNA; pyroptosis.

Publication types

Review