The mediation role of sleep quality in the relationship between cognitive decline and depression

Xiaolei Liu; Xin Xia; Fengjuan Hu; Qiukui Hao; Lisha Hou; Xuelian Sun; Gongchang Zhang; Jirong Yue; Birong Dong

doi:10.1186/s12877-022-02855-5

The mediation role of sleep quality in the relationship between cognitive decline and depression

BMC Geriatr. 2022 Mar 3;22(1):178. doi: 10.1186/s12877-022-02855-5.

Authors

Xiaolei Liu^#^{1

2}, Xin Xia^#^{1

2}, Fengjuan Hu^{1

2}, Qiukui Hao^{1

2}, Lisha Hou^{1

2}, Xuelian Sun^{1

2}, Gongchang Zhang^{1

2}, Jirong Yue^{1

2}, Birong Dong^{3

4}

Affiliations

¹ National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan Province, China.
² Geriatric Health Care and Medical Research Center, Sichuan University, Chengdu, Sichuan Province, China.
³ National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan Province, China. birongdong123@outlook.com.
⁴ Geriatric Health Care and Medical Research Center, Sichuan University, Chengdu, Sichuan Province, China. birongdong123@outlook.com.

^# Contributed equally.

Abstract

Objectives: Associations between cognitive decline and depression have been inconclusive. We examined 1) whether sleep quality mediates these relationships and 2) which factor of sleep quality mediates these relationships.

Methods: This study utilized baseline data from the 2018 West China Health and Aging Trend study (WCHAT), a large cohort data-set that including participants aged over 50 years old. We defined depression using the 15-item Geriatric Depression Scale (GDS-15). Cognitive status was measured using the Short Portable Mental Status Questionnaire (SPMSQ) and sleep quality was assessed using the Pittsburgh sleep quality index (PSQI). Direct relationships between cognitive decline, sleep quality and depression were assessed using multiple linear regression. Mediation models and structural equation model (SEM) pathway analysis were used to test the mediating role of specific aspects of sleep (e.g., quality, duration) in the relationship between cognitive decline and depression.

Results: Of 6828 participants aged 50 years old or older, the proportion of depression was 17.4%. Regression analysis indicated a total association between cognitive scores (β = 0.251, 95% CI 0.211 to 0.290, p < 0.001) and depression status. After adjusted PSQI scores, the association between cognitive scores and depression status was still significant (β = 0.242, 95% CI 0.203 to 0.281, p < 0.001), indicating a partial mediation effect of sleep quality. Mediation analysis verified sleep quality partially mediate the associations between cognitive decline and depression (indirect effect estimate = 0.0308, bootstrap 95% CI 0.023 to 0.040; direct effect estimate = 0.3124, bootstrap 95% CI 0.269 to 0.350). And daytime dysfunction had a highest mediation effect with a proportion of mediation up to 14.6%.

Conclusions: Sleep quality partially mediated the relationship between cognitive decline and depression. Daytime dysfunction had a highest mediation effect. Further research is necessary to examine the effects of sleep quality on the relationship of cognitive decline and depression.

Keywords: Cognitive decline; Depression; Mediation analysis; Sleep quality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
China / epidemiology
Cognitive Dysfunction* / diagnosis
Cognitive Dysfunction* / epidemiology
Depression* / diagnosis
Depression* / epidemiology
Depression* / psychology
Humans
Sleep
Sleep Quality