Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation. Interleukin-34 (IL-34) is a new member of the interleukin family discovered in recent years. It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colony stimulating factor-1 receptor, and it is closely related to inflammatory and autoimmune diseases. IL-34 is highly expressed in patients with coronary heart disease or diabetes mellitus. IL-34 induces atherosclerosis and insulin resistance through multiple pro-inflammatory actions, ultimately leading to the occurrence and development of coronary heart disease, type 2 diabetes, and their comorbidities.
冠心病和糖尿病与慢性低度炎症密切相关。白细胞介素-34(interleukin-34，IL-34)是近年来发现的一种促炎因子，主要通过与集落刺激因子-1受体(colony stimulating factor-1 receptor，CSF-1R)结合，参与单核巨噬细胞系统的病理生理过程，与机体炎症和自身免疫性疾病密切相关。IL-34在冠心病、糖尿病患者体内高表达，它通过多途径发挥促炎作用，诱发动脉粥样硬化和胰岛素抵抗，最终导致冠心病、2型糖尿病及其共病的发生和发展。.
Keywords: coronary heart disease; diabetes mellitus; inflammatory factor; interleukin-34; mononuclear phagocyte system.