Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos

Affiliations

• ¹ Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China.
• ² Center for Reproductive Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
• ³ Center for Stem Cell Biology and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
• ⁴ Department of Basic Medical Science, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand.
• ⁵ School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Pudong New Area, Shanghai 201210, China.
• ⁶ School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Pudong New Area, Shanghai 201210, China. Electronic address: ligl@shanghaitech.edu.cn.
• ⁷ Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: rcchian@tongji.edu.cn.