Quercetin is a substrate not an inhibitor of tyrosinase - comments on "Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism" published by Fan et al. (2017)

Hubert Wojtasek

doi:10.1016/j.foodres.2022.110944

Quercetin is a substrate not an inhibitor of tyrosinase - comments on "Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism" published by Fan et al. (2017)

Food Res Int. 2022 Mar:153:110944. doi: 10.1016/j.foodres.2022.110944. Epub 2022 Jan 7.

Author

Hubert Wojtasek¹

Affiliation

¹ Institute of Chemistry, Opole University, Ul. Oleska 48, 45-052 Opole, Poland. Electronic address: Hubert.Wojtasek@uni.opole.pl.

PMID: 35227469
DOI: 10.1016/j.foodres.2022.110944

Abstract

Quercetin was described as an inhibitor of tyrosinase in an article published in Food Research International. However, it was firmly established in the literature before that this compound was a substrate of this enzyme and an antioxidant reducing tyrosinase-generated o-quinones.

Keywords: Flavonoids; Quercetin; Tyrosinase.

Publication types

Letter
Comment

MeSH terms

Antioxidants / pharmacology
Monophenol Monooxygenase* / antagonists & inhibitors
Quercetin* / chemistry
Quercetin* / pharmacology

Substances

Antioxidants
Quercetin
Monophenol Monooxygenase