Subacute Cutaneous Lupus as a Paraneoplastic Manifestation of Non-Hodgkin Lymphoma

J Investig Med High Impact Case Rep. 2022 Jan-Dec:10:23247096211063066. doi: 10.1177/23247096211063066.

Abstract

Malignancies have been associated with paraneoplastic syndromes, such as dermatomyositis. Subacute cutaneous lupus erythematosus (SCLE) can occur due to a wide array of cancers. Paraneoplastic SCLE obeys McLean's criteria and often regresses after the underlying malignancy has been treated appropriately. Anti-Ro/SSA antibodies are often present in patients with paraneoplastic SCLE; however, there have been many instances where anti-Ro may not be present. We report a case of non-Hodgkin lymphoma causing SCLE, a malignancy not previously known to be associated with paraneoplastic SCLE. We also highlight the importance of perhaps prompt chemotherapy to treat the underlying malignancy, as a failure to do so may lead to worse patient outcomes.

Keywords: follicular B-cell lymphoma; non-Hodgkin’s lymphoma; paraneoplastic syndrome; subacute cutaneous lupus erythematosus.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies
  • Humans
  • Lupus Erythematosus, Cutaneous* / diagnosis
  • Lupus Erythematosus, Cutaneous* / etiology
  • Lymphoma, Non-Hodgkin* / complications
  • Lymphoma, Non-Hodgkin* / diagnosis
  • Paraneoplastic Syndromes* / etiology

Substances

  • Autoantibodies