Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique

Siti Machmudah; Rizky Prasetya Mahardika; Syahna Almadilla; Sugeng Winardi; Wahyudiono; Hideki Kanda; Motonobu Goto

doi:10.1021/acsomega.1c06911

Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique

ACS Omega. 2022 Feb 8;7(7):6345-6353. doi: 10.1021/acsomega.1c06911. eCollection 2022 Feb 22.

Authors

Siti Machmudah¹, Rizky Prasetya Mahardika¹, Syahna Almadilla¹, Sugeng Winardi¹, Wahyudiono², Hideki Kanda², Motonobu Goto²

Affiliations

¹ Department of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo, Surabaya 60111, Indonesia.
² Department of Materials Process Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

Abstract

Fine particles comprising Curcuma xanthorrhiza Roxb (C. xanthorrhiza) rhizome extract were successfully generated using a supercritical carbon dioxide (SCCO₂) antisolvent technique. The SCCO₂ antisolvent process was performed at 40 °C with 8-16 MPa operating pressures. The CO₂ and feed solution flow rates were 15 and 0.25 mL min^-1, respectively. The mixture of C. xanthorrhiza rhizome extract and a polyvinylpyrrolidone (PVP) polymer in acetone-ethanol was used as a feed solution. The collected particle products seemed to possess spherical and spherical-like morphologies with a diameter of less than 500 nm. The infrared spectroscopy analysis showed that the structural properties of C. xanthorrhiza rhizome extract did not change after treatment with the SCCO₂ antisolvent. Furthermore, the addition of the PVP polymer in the C. xanthorrhiza rhizome extract particle products may improve their dissolution significantly in an aqueous solution medium.