Neonatal Cerebral Venous Thrombosis following Maternal SARS-CoV-2 Infection in Pregnancy

Neonatology. 2022;119(2):268-272. doi: 10.1159/000520537. Epub 2022 Feb 25.

Abstract

A possible consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the development of an exacerbated thrombophilic status, and cerebral venous thrombosis (CVT) is a rare but possible complication of SARS-CoV-2 infection reported both in adults and in children. The present case report describes the clinical course of a term neonate showing extended CVT of unclear origin, whose mother had developed SARS-CoV-2 infection during the third trimester of pregnancy. We speculate that the prothrombotic status induced by maternal SARS-CoV-2 infection may have played a pathophysiological role in the development of such severe neonatal complication. Further investigations are required to confirm such hypothesis.

Keywords: Cerebral venous thrombosis; Magnetic resonance imaging; Neonate; Pregnancy; SARS-CoV-2.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19* / complications
  • Child
  • Family
  • Female
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Intracranial Thrombosis* / diagnostic imaging
  • Intracranial Thrombosis* / etiology
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Outcome
  • SARS-CoV-2
  • Venous Thrombosis* / complications