Carbon-ion Radiotherapy for Inoperable Head and Neck Bone and Soft-tissue Sarcoma: Prospective Observational Study

Anticancer Res. 2022 Mar;42(3):1439-1446. doi: 10.21873/anticanres.15614.

Abstract

Background/aim: Bone and soft-tissue sarcomas of the head and neck have very poor prognoses. This prospective study aimed to investigate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for bone and soft-tissue sarcoma of the head and neck.

Patients and methods: The present study was a prospective clinical study that included 10 consecutive patients diagnosed with bone and soft-tissue sarcoma of the head and neck who were treated with C-ion RT between 2012 and 2018 at our institution. C-Ion RT consisted of 70.4 Gy (relative biological effectiveness) in 16 fractions.

Results: The 3-year local control, overall survival, and progression-free survival rates for patients overall were 72.9%, 77.8%, and 36%, respectively.

Conclusion: The present study demonstrated the efficacy of C-ion RT for bone and soft-tissue sarcoma of the head and neck; adverse events were within the expected range.

Keywords: Bone and soft-tissue sarcoma; carbon-ion radiotherapy; head and neck tumor.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / pathology
  • Head and Neck Neoplasms / radiotherapy*
  • Heavy Ion Radiotherapy* / adverse effects
  • Heavy Ion Radiotherapy* / mortality
  • Humans
  • Male
  • Middle Aged
  • Osteosarcoma / mortality
  • Osteosarcoma / pathology
  • Osteosarcoma / radiotherapy*
  • Progression-Free Survival
  • Prospective Studies
  • Radiation Dosage*
  • Sarcoma / mortality
  • Sarcoma / pathology
  • Sarcoma / radiotherapy*
  • Time Factors
  • Young Adult