Glucose-derived posttranslational modification in cardiovascular disease

Michael Lehrke; Julia Moellmann; Florian Kahles; Nikolaus Marx

doi:10.1016/j.mam.2022.101084

Glucose-derived posttranslational modification in cardiovascular disease

Mol Aspects Med. 2022 Aug:86:101084. doi: 10.1016/j.mam.2022.101084. Epub 2022 Feb 24.

Authors

Michael Lehrke¹, Julia Moellmann², Florian Kahles², Nikolaus Marx²

Affiliations

¹ Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany. Electronic address: mlehrke@ukaachen.de.
² Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.

PMID: 35219502
DOI: 10.1016/j.mam.2022.101084

Abstract

Glucose and its metabolites provide building blocks for cellular structures and modifications occurring on proteins, lipids and nucleotides. The underlying reactions consist of glycosylations controlled by hundreds of enzymes following a specific yet incompletely understood architecture of cell physiology and glycations as random, not controlled modifications occurring in an oxidative environment. In both cases attachments of glucose or its metabolites can modulate the tertiary structure of proteins as required for cellular physiology or cause disturbance with disease driving pathology. In this review we will discuss the relevance of glucose dependent cellular modifications for cardiovascular complications.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cardiovascular Diseases*
Glucose*
Glycosylation
Humans
Oxidation-Reduction
Protein Processing, Post-Translational
Proteins

Substances

Proteins
Glucose