Genome-wide analyses of nonsyndromic cleft lip with or without palate identify 20 new risk loci in the Chinese Han population

Bao Li; Liang Yong; Yafen Yu; Yanqin Yu; Qi Zhen; Huiyao Ge; Yiwen Mao; Weiwei Chen; Yanxia Yu; Yirui Wang; Zhuo Li; Wencheng Fan; Chang Zhang; Xia Hu; Ruixue Zhang; Lu Cao; Hao Liu; Zhuan Bian; Miao He; Liangdan Sun

doi:10.1016/j.jgg.2022.02.004

Genome-wide analyses of nonsyndromic cleft lip with or without palate identify 20 new risk loci in the Chinese Han population

J Genet Genomics. 2022 Sep;49(9):903-905. doi: 10.1016/j.jgg.2022.02.004. Epub 2022 Feb 22.

Authors

Bao Li¹, Liang Yong¹, Yafen Yu¹, Yanqin Yu², Qi Zhen³, Huiyao Ge³, Yiwen Mao³, Weiwei Chen³, Yanxia Yu³, Yirui Wang³, Zhuo Li³, Wencheng Fan³, Chang Zhang³, Xia Hu³, Ruixue Zhang³, Lu Cao³, Hao Liu³, Zhuan Bian², Miao He⁴, Liangdan Sun⁵

Affiliations

¹ Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China; Institute of Dermatology, Anhui Medical University, Hefei, China; Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230022, China; Anhui Provincial Institute of Translational Medicine, Hefei, Anhui 230022, China.
² The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China.
³ Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China; Institute of Dermatology, Anhui Medical University, Hefei, Anhui 230022, China; Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230022, China; Anhui Provincial Institute of Translational Medicine, Hefei, Anhui 230022, China.
⁴ The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China. Electronic address: hemiao@whu.edu.cn.
⁵ Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China; Institute of Dermatology, Anhui Medical University, Hefei, Anhui 230022, China; Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230022, China; Anhui Provincial Institute of Translational Medicine, Hefei, Anhui 230022, China. Electronic address: ahmusld@163.com.

PMID: 35217232
DOI: 10.1016/j.jgg.2022.02.004

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Case-Control Studies
China / epidemiology
Cleft Lip* / epidemiology
Cleft Lip* / genetics
Cleft Palate* / epidemiology
Cleft Palate* / genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Palate
Polymorphism, Single Nucleotide / genetics