Circulation of an Artemisinin-Resistant Malaria Lineage in a Traveler Returning from East Africa to France

Clin Infect Dis. 2022 Sep 30;75(7):1242-1244. doi: 10.1093/cid/ciac162.

Abstract

A returned traveler to Uganda presented with a Plasmodium falciparum kelch13 A675V mutant infection that exhibited delayed clearance under artesunate therapy. Parasites were genetically related to recently reported Ugandan artemisinin-resistant A675V parasites. Adequate malaria prevention measures and clinical and genotypic surveillance are important tools to avoid and track artemisinin resistance.

Keywords: Plasmodium falciparum; East Africa; artemisinin resistance; kelch13; whole-genome sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials* / pharmacology
  • Antimalarials* / therapeutic use
  • Artemisinins* / pharmacology
  • Artemisinins* / therapeutic use
  • Artesunate / therapeutic use
  • Drug Resistance / genetics
  • Humans
  • Malaria, Falciparum* / drug therapy
  • Malaria, Falciparum* / epidemiology
  • Malaria, Falciparum* / parasitology
  • Plasmodium falciparum / genetics
  • Protozoan Proteins
  • Uganda

Substances

  • Antimalarials
  • Artemisinins
  • Protozoan Proteins
  • Artesunate
  • artemisinin