Quality Related Safety Evaluation of a South African Traditional Formulation (PHELA®) as Novel Anti-Biofilm Candidate

Molecules. 2022 Feb 11;27(4):1219. doi: 10.3390/molecules27041219.

Abstract

A South African traditional formulation, PHELA®, is consumed by the traditional people for severe chest problems with coughing, diarrhea, oral ulcers etc. The present study focused on establishing the anti-infective properties of a safe and standardized poly-herbal formulation through a series of criteria and specifications.

Keywords: PHELA®; RP-HPLC; South African traditional preparation; antibacterial; biofilm; herb-drug interaction.

MeSH terms

  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Biofilms / drug effects*
  • Chromatography, High Pressure Liquid
  • Dose-Response Relationship, Drug
  • Humans
  • Mass Spectrometry
  • Medicine, African Traditional*
  • Microbial Sensitivity Tests
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*

Substances

  • Anti-Infective Agents
  • Plant Extracts