Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19

Wojciech Szypowski; Aleksander Dębiec; Jarosław Świstak; Maciej Nowocień; Piotr Rzepecki; Marcin Możański; Jacek Staszewski; Adam Stępień

doi:10.3390/life12020168

Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19

Life (Basel). 2022 Jan 24;12(2):168. doi: 10.3390/life12020168.

Authors

Wojciech Szypowski¹, Aleksander Dębiec¹, Jarosław Świstak¹, Maciej Nowocień², Piotr Rzepecki³, Marcin Możański⁴, Jacek Staszewski¹, Adam Stępień¹

Affiliations

¹ Clinic of Neurology, Military Institute of Medicine, 04-141 Warsaw, Poland.
² Medical Diagnostic Imaging, Military Institute of Medicine, 04-141 Warsaw, Poland.
³ Clinic of Haematology, Military Institute of Medicine, 04-141 Warsaw, Poland.
⁴ Clinic of Anaesthesiology and Intensive Care, Military Institute of Medicine, 04-141 Warsaw, Poland.

Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous sinus thrombosis (CVST) has been recently reported after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We present a case of a patient with fulminant CVST and thrombocytopenia after receiving the ChAdOx1 nCoV-19 vaccine. Although the patient received immediate anticoagulant and intravenous immune globulin treatment, he died within 24 h after hospital admission. VITT and CVST are rare conditions; however, the course may be fatal. Therefore, clinicians should be familiarized with the clinical and laboratory features of VITT.

Keywords: COVID-19; COVID-19 vaccine; CVST; VITT; thrombocytopenia.

Publication types

Case Reports