Specifically Regional Cerebral Hypoperfusion in a Case of Highly Suspected Sporadic Creutzfeldt-Jakob Disease on 99mTc-ECD SPECT/CT with Easy Z-Score Imaging System Analysis

Shun-Chieh Chen; Daniel Hueng-Yuan Shen; Hung-Yen Chan; Ming-Hui Yang; Hung-Pin Chan

doi:10.3390/diagnostics12020437

Specifically Regional Cerebral Hypoperfusion in a Case of Highly Suspected Sporadic Creutzfeldt-Jakob Disease on ^99mTc-ECD SPECT/CT with Easy Z-Score Imaging System Analysis

Diagnostics (Basel). 2022 Feb 8;12(2):437. doi: 10.3390/diagnostics12020437.

Authors

Shun-Chieh Chen¹, Daniel Hueng-Yuan Shen¹, Hung-Yen Chan^{1

2}, Ming-Hui Yang³, Hung-Pin Chan¹

Affiliations

¹ Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
² Graduate Institute of Science and Technology Law, National Kaohsiung University of Science and Technology, Kaohsiung 80778, Taiwan.
³ Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly-progressive dementing illness, the challenge of diagnosis during life. We presented a 78-year-old woman reported stupor, right facial palsy, and fluctuations in consciousness. ^99mTc-ECD brain SPECT/CT with eZIS analysis revealed significant decreased regional cerebral blood flow mainly in specific regions of Alzheimer's disease as the published article reported with involving frontal region. Brain DWI MRI increased signal intensities corresponding to similar location of ^99mTc-ECD brain SPECT/CT. In this case, we reported the pattern of decreased rCBF may correlate to rapidly progressive dementia and associated neurodegenerative symptoms of the highly suspected sCJD patient.

Keywords: 99mTc-ECD brain SPECT; Creutzfeldt-Jakob Disease; MRI; SPECT/CT; cerebral hypoperfusion.