We evaluated disseminated histoplasmosis (DH) in HIV patients over 10 years in southern Brazil. The incidence was 12 cases/1,000 hospitalizations (2010-2019); the mortality rate was 35%. Tuberculosis frequently obscured the diagnosis of DH. We emphasize the need in our region to suspect and investigate DH using more sensitive methods.
Keywords: Brazil; HIV/AIDS and other retroviruses; Histoplasma capsulatum; bacteria; histoplasmosis; mycoses; pulmonary disease; tuberculosis and other mycobacteria.