Research progress in the screening and evaluation of umami peptides

Compr Rev Food Sci Food Saf. 2022 Mar;21(2):1462-1490. doi: 10.1111/1541-4337.12916. Epub 2022 Feb 24.

Abstract

Umami is an important element affecting food taste, and the development of umami peptides is a topic of interest in food-flavoring research. The existing technology used for traditional screening of umami peptides is time-consuming and labor-intensive, making it difficult to meet the requirements of high-throughput screening, which limits the rapid development of umami peptides. The difficulty in performing a standard measurement of umami intensity is another problem that restricts the development of umami peptides. The existing methods are not sensitive and specific, making it difficult to achieve a standard evaluation of umami taste. This review summarizes the umami receptors and umami peptides, focusing on the problems restricting the development of umami peptides, high-throughput screening, and establishment of evaluation standards. The rapid screening of umami peptides was realized based on molecular docking technology and a machine learning method, and the standard evaluation of umami could be realized with a bionic taste sensor. The progress of rapid screening and evaluation methods significantly promotes the study of umami peptides and increases its application in the seasoning industry.

Keywords: bionic taste sensor; machine learning; molecular docking; umami peptides; umami receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Molecular Docking Simulation
  • Peptides* / chemistry
  • Taste*

Substances

  • Peptides