This study proposes an approach to generate a uniform flat-top beam with a liquid crystal spatial light modulator (LC-SLM) to optimize ultrasensitive inertial measurement. The random incomplete Gaussian beam is modulated into a flat-top beam by uploading a beam shaping optimization algorithm on an LC-SLM. Simulation results verify the effectiveness of the proposed method. The beam obtained from the experimental results with the 4f filter system optimization also conforms to the properties of the generated flat-top beam. Compared to existing beam shaping algorithms for simulation and experimental analysis, the beam shaping design based on the LC-SLM to optimize the ultrasensitive inertial measurement is realized. This method has also been verified to be effective in beam shaping in various beam situations. The application of this method in ultrahigh-sensitivity inertial measurement should prove significant.