Metabolomics and its Applications in Cancer Cachexia

Pengfei Cui; Xiaoyi Li; Caihua Huang; Qinxi Li; Donghai Lin

doi:10.3389/fmolb.2022.789889

Metabolomics and its Applications in Cancer Cachexia

Front Mol Biosci. 2022 Feb 7:9:789889. doi: 10.3389/fmolb.2022.789889. eCollection 2022.

Authors

Pengfei Cui¹, Xiaoyi Li², Caihua Huang³, Qinxi Li⁴, Donghai Lin⁵

Affiliations

¹ College of Food and Pharmacy, Xuchang University, Xuchang, China.
² Xuchang Central Hospital, Xuchang, China.
³ Department of Physical Education, Xiamen University of Technology, Xiamen, China.
⁴ State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
⁵ Key Laboratory for Chemical Biology of Fujian Province, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Abstract

Cancer cachexia (CC) is a complicated metabolic derangement and muscle wasting syndrome, affecting 50-80% cancer patients. So far, molecular mechanisms underlying CC remain elusive. Metabolomics techniques have been used to study metabolic shifts including changes of metabolite concentrations and disturbed metabolic pathways in the progression of CC, and expand further fundamental understanding of muscle loss. In this article, we aim to review the research progress and applications of metabolomics on CC in the past decade, and provide a theoretical basis for the study of prediction, early diagnosis, and therapy of CC.

Keywords: biomarker; cancer cachexia; metabolic alterations; metabolomics; progress.

Publication types

Review