Surgical and mediastinal emphysema in critically ill COVID-19 patients: A multicentric experience

Yasser Aljehani; Auday A Alkhunaizi; Sharifah A Othman; Hassan Abdullah Alqumber; Yousif Almubarak; Tariq Al-Musawi; Mohammed Ibrahim Al Bazroun; Khatoon Alshaikhmohamed

doi:10.4103/atm.atm_600_20

Surgical and mediastinal emphysema in critically ill COVID-19 patients: A multicentric experience

Ann Thorac Med. 2022 Jan-Mar;17(1):51-58. doi: 10.4103/atm.atm_600_20. Epub 2022 Jan 14.

Authors

Yasser Aljehani¹, Auday A Alkhunaizi², Sharifah A Othman¹, Hassan Abdullah Alqumber³, Yousif Almubarak⁴, Tariq Al-Musawi⁵, Mohammed Ibrahim Al Bazroun², Khatoon Alshaikhmohamed³

Affiliations

¹ Division of Thoracic Surgery, Department of Surgery, King Fahad Hospital of the University, College of Medicine, Imam Abdulrahman Bin Faisal University, Damam, Saudi Arabia.
² Department of Emergency Medicine, Qatif Central Hospital, Qatif, Saudi Arabia.
³ Department of Surgery, Qatif Central Hospital, Qatif, Saudi Arabia.
⁴ Department of Critical Care, King Fahad Hospital of the University, College of Medicine, Imam Abdulrahman Bin Faisal University, Damam, Saudi Arabia.
⁵ Department of Critical Care, Dr. Sulaiman Al Habib Hospital, AL Khobar, Saudi Arabia.

Abstract

Introduction: Coronavirus illness 2019, commonly referred to as COVID-19, is a highly infectious disease brought on by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 was declared a universal pandemic in March 2020 by the World Health Organization and is a severe health issue with unprecedented morbidity and mortality rates. Both surgical and mediastinal emphysema have been seen in cases of critically ill COVID-19 patients in several hospitals in the Eastern Province of Saudi Arabia.

Methods: This was a retrospective, cross-sectional, multicentric study involving several hospitals in the Saudi Arabian Eastern Province. Data were collected from intensive care units (ICUs) in these hospitals from March 2 to August 2, 2020. The inclusion criteria consisted of all patients who tested positive for SARS-CoV-2 and were admitted to a critical care unit.

Results: Thirty patients required thoracic consultation and management, including 26 males (81.3%) and 4 females (12.5%) (1:0.15) who developed surgical and mediastinal emphysema requiring thoracic surgery intervention. Most of the patients were on high ventilation settings, and the mean duration of ventilator support was 16.50 ± 13.98 days. Two patients (6.3%) required reintubation. The median positive end-expiratory pressure (PEEP) was 12 ± 2.80 cmH₂O with a median FiO2 of 70% ± 19.73. On average, thoracic complications occurred on day 3 (±6.29 days) postintubation. Ten patients (33.33%) experienced a pneumothorax associated with surgical emphysema (SE), 1 patient (3.33%) presented with only mediastinal emphysema; 17 patients (56.66%) with only SE, and 1 (3.33%) had mediastinal emphysema associated with SE. We noted a correlation between the duration of ventilator support, the length of ICU stay (P < 0.001), and the total length of stay (LOS) in the hospital (P < 0.001). Total length of hospital stay showed significant association with the onset of complications (P = 0.045) and outcomes (P = 0.006). A significant association between PEEP and the duration of ventilator support was also evident with a P value = 0.009 and the onset of complications (P = 0.043). In addition, we found a significant association between the group with pneumothorax in combination with SE, and their outcomes, with a P = 0.002.

Conclusion: Surgical and mediastinal emphysema in the critically ill patients are usually attributed to barotrauma and high ventilations settings. During COVID-19 pandemic, these entities were seen and the pathogenesis was revisited and some attributed its presence to the disease process and destruction on lung parenchyma. The associated with extended LOS and delayed recovery in addition to poor prognosis were seen. Their presence is an indicator to higher morbidity and mortality.

Keywords: COVID-19; emphysema; mediastinal; pneumothorax; surgical.