Progress in the treatment of diabetic peripheral neuropathy

Ke Yang; Yue Wang; Yi-Wei Li; Yi-Gong Chen; Na Xing; Han-Bin Lin; Ping Zhou; Xiao-Ping Yu

doi:10.1016/j.biopha.2022.112717

Progress in the treatment of diabetic peripheral neuropathy

Biomed Pharmacother. 2022 Apr:148:112717. doi: 10.1016/j.biopha.2022.112717. Epub 2022 Feb 19.

Authors

Ke Yang¹, Yue Wang², Yi-Wei Li², Yi-Gong Chen³, Na Xing⁴, Han-Bin Lin⁵, Ping Zhou⁶, Xiao-Ping Yu⁷

Affiliations

¹ Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Science, China Jiliang University, Hangzhou 310018, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
² Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Science, China Jiliang University, Hangzhou 310018, China.
³ Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Xiacheng District, Hangzhou, Zhejiang 310014, China.
⁴ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; Zhongshan Institute for Drug Discovery, SIMM, CAS, Zhongshan 528400, Guangdong, China.
⁵ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; Zhongshan Institute for Drug Discovery, SIMM, CAS, Zhongshan 528400, Guangdong, China. Electronic address: linhanbin@simm.ac.cn.
⁶ Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing100191, China. Electronic address: zhoup0520@163.com.
⁷ Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Science, China Jiliang University, Hangzhou 310018, China. Electronic address: yxp@cjlu.edu.cn.

PMID: 35193039
DOI: 10.1016/j.biopha.2022.112717

Abstract

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Symptoms of DPN mainly include spontaneous intractable pain that is diffuse and continuous and can last from several weeks to several months. DPN is associated with a high mortality rate and poor prognosis. Its pathogenesis is not fully understood, and clinical treatment is focused on relieving its clinical symptoms, as well as improving blood sugar control and cardiovascular risk factors. DPN and its clinically effective treatments need to be studied. This study discusses the treatment methods and pathogenesis of DPN, summarizes the related research progress, and attempts to provide a reference for DPN research.

Keywords: Acupuncture; Chemical medicine; Diabetes Mellitus; Peripheral Nervous System Diseases; Traditional Chinese medicine.

Publication types

Review

MeSH terms

Diabetes Mellitus*
Diabetic Neuropathies* / complications
Diabetic Neuropathies* / drug therapy
Humans
Pain / complications
Treatment Outcome