Lot-to-lot reagent verification: challenges and possible solutions

Abstract

Lot-to-lot verification is an important laboratory activity that is performed to monitor the consistency of analytical performance over time. In this opinion paper, the concept, clinical impact, challenges and potential solutions for lot-to-lot verification are exained.

Keywords: analytical variation; between-lot verification; external quality assurance; lot-to-lot verification; moving averages; patient-based quality control; quality control; reagent verification.