Catch and release: freeing up PD-L1 ameliorates autoimmunity

Stephanie Grebinoski; Angela M Gocher-Demske; Dario A A Vignali

doi:10.1038/s41590-022-01140-2

Catch and release: freeing up PD-L1 ameliorates autoimmunity

Nat Immunol. 2022 Mar;23(3):344-346. doi: 10.1038/s41590-022-01140-2.

Authors

Stephanie Grebinoski^#^{1

2

3}, Angela M Gocher-Demske^#^{1

3}, Dario A A Vignali^#^{4

5

6}

Affiliations

¹ Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
³ Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
⁴ Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dvignali@pitt.edu.
⁵ Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.
⁶ Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.

^# Contributed equally.

Abstract

The binding of PD-L1 to CD80 on antigen-presenting cells prevents PD-1 ligation on T cells. Therapeutic blockade of the cis-PD-L1–CD80 interaction liberates PD-L1 to bind to PD-1, inhibits autoreactive T cells and robustly alleviates autoimmune symptoms.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Autoimmunity* / immunology
B7-H1 Antigen* / immunology
Lymphocyte Activation
Programmed Cell Death 1 Receptor / immunology
T-Lymphocytes / immunology

Substances

B7-H1 Antigen
Programmed Cell Death 1 Receptor

Abstract

Publication types

MeSH terms

Substances

Grants and funding