Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Imtiaz A Khan; Magali Moretto

doi:10.1016/j.pt.2022.01.010

Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Trends Parasitol. 2022 Apr;38(4):272-273. doi: 10.1016/j.pt.2022.01.010. Epub 2022 Feb 19.

Authors

Imtiaz A Khan¹, Magali Moretto²

Affiliations

¹ Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA. Electronic address: Imti56@gwu.edu.
² Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA. Electronic address: morettom@gwu.edu.

PMID: 35190281
DOI: 10.1016/j.pt.2022.01.010

Abstract

Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge.

Keywords: B cells; CD8 T cells; Nfkbid; Toxoplasma gondii; vaccine.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Antibodies, Protozoan
Immunity, Cellular
Immunity, Humoral
Mice
Mice, Inbred C57BL
Protozoan Proteins
Protozoan Vaccines*
Toxoplasma* / genetics
Toxoplasmosis*
Toxoplasmosis, Animal*
Vaccines, DNA*

Substances

Antibodies, Protozoan
Protozoan Proteins
Protozoan Vaccines
Vaccines, DNA

Abstract

Publication types

MeSH terms

Substances

Grants and funding