A kinetic mechanism for systems-level behavior in GTPase signaling

Noel Jameson; Maire Gavagan; Jesse G Zalatan

doi:10.1016/j.tibs.2022.01.006

A kinetic mechanism for systems-level behavior in GTPase signaling

Trends Biochem Sci. 2022 Jun;47(6):459-460. doi: 10.1016/j.tibs.2022.01.006. Epub 2022 Feb 19.

Authors

Noel Jameson¹, Maire Gavagan¹, Jesse G Zalatan²

Affiliations

¹ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
² Department of Chemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: zalatan@uw.edu.

Abstract

GTPase switches are hubs for multiple distinct cell signaling inputs and outputs. In a new study combining genetic and biochemical methods, Perica, Mathy et al. identify an unexpected connection between the kinetics of a GTPase switch cycle and functional specificity.

Keywords: GTPase; Gsp1; RAN; cell signaling; specificity; switch kinetics.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

GTP Phosphohydrolases / metabolism
Kinetics
Nuclear Proteins / metabolism
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins* / metabolism
Signal Transduction

Substances

Nuclear Proteins
Saccharomyces cerevisiae Proteins
GTP Phosphohydrolases

Grants and funding

R35 GM124773/GM/NIGMS NIH HHS/United States