Pharmacokinetics and pharmacodynamics of peptide antibiotics

Xingchen Bian; Xingyi Qu; Jing Zhang; Sue C Nang; Phillip J Bergen; Qi Tony Zhou; Hak-Kim Chan; Meiqing Feng; Jian Li

doi:10.1016/j.addr.2022.114171

Pharmacokinetics and pharmacodynamics of peptide antibiotics

Adv Drug Deliv Rev. 2022 Apr:183:114171. doi: 10.1016/j.addr.2022.114171. Epub 2022 Feb 18.

Authors

Xingchen Bian¹, Xingyi Qu², Jing Zhang³, Sue C Nang⁴, Phillip J Bergen⁴, Qi Tony Zhou⁵, Hak-Kim Chan⁶, Meiqing Feng⁷, Jian Li⁸

Affiliations

¹ Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; School of Pharmacy, Fudan University, Shanghai, China.
² Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; School of Pharmacy, Fudan University, Shanghai, China; Phase I Unit, Huashan Hospital, Fudan University, Shanghai 200040, China.
³ Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; Phase I Unit, Huashan Hospital, Fudan University, Shanghai 200040, China.
⁴ Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Australia.
⁵ Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN, USA.
⁶ Advanced Drug Delivery Group, School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
⁷ School of Pharmacy, Fudan University, Shanghai, China.
⁸ Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Australia. Electronic address: jian.li@monash.edu.

Abstract

Antimicrobial resistance is a major global health challenge. As few new efficacious antibiotics will become available in the near future, peptide antibiotics continue to be major therapeutic options for treating infections caused by multidrug-resistant pathogens. Rational use of antibiotics requires optimisation of the pharmacokinetics and pharmacodynamics for the treatment of different types of infections. Toxicodynamics must also be considered to improve the safety of antibiotic use and, where appropriate, to guide therapeutic drug monitoring. This review focuses on the pharmacokinetics/pharmacodynamics/toxicodynamics of peptide antibiotics against multidrug-resistant Gram-negative and Gram-positive pathogens. Optimising antibiotic exposure at the infection site is essential for improving their efficacy and minimising emergence of resistance.

Keywords: Antibiotics; Antimicrobial peptide; Antimicrobial resistance; Pharmacodynamics; Pharmacokinetics; Safety; Therapeutic drug monitoring.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Anti-Bacterial Agents* / pharmacokinetics
Drug Monitoring*
Drug Resistance, Multiple, Bacterial
Humans
Peptides / pharmacology

Substances

Anti-Bacterial Agents
Peptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding