Objective: To analyze the epidemiological characteristics of hand, foot and mouth disease (HFMD) among people ≥6 years old in Beijing from 2011 to 2020. Methods: The incidence data of HFMD cases from 2011 to 2020 were collected from the National Notifiable Infectious Disease Reporting System of China Information for Disease Control and Prevention and the etiological surveillance of HFMD in 29 sentinel hospitals from 16 districts of Beijing. Descriptive epidemiological methods were used to analyze the distributions, pathogen constituents, and changes of HFMD cases in Beijing people ≥6 years old. Results: From 2011 to 2020, a total of 38 183 cases of HFMD were reported among people ≥6 years old in Beijing, of which 46 (0.12%) cases were severe. The average annual reported incidence was 19.04/100 000. The ratio of males to females were 1.37∶1(22 064∶16 119). The proportion of HFMD in people ≥6 years old increased from 7.56%(2 606/34 488) in 2011 to 24.54% (546/2 225) in 2020. The average incidence of HFMD was higher in Shunyi district, Yanqing district, and Tongzhou district than in other districts in Beijing. The positive rate of enterovirus in sentinel surveillance was 66.78% (1 976/2 959), the proportion of enterovirus group A 71 (EV-A71) was 45.29% (101/223) in 2014, no EV-A71 positive was detected in 2020, and the proportion of Coxsackievirus A 6 (CV-A6) increased from 15.11% (34/225) in 2016 to 81.08% (60/74) in 2020. Conclusions: From 2011 to 2020, the proportion of cases with HFMD in people ≥6 years old in Beijing increased yearly, and the proportion of EV-A71 positive patients decreased basically. Since 2016, CV-A6 has gradually become the dominant pathogen. More attention should be paid to the epidemic situation and dynamic pathogen changes of hand foot mouth disease in people ≥6 years old.
目的： 分析2011-2020年北京市≥6岁人群手足口病流行特征。 方法： 资料来源于中国疾病预防控制信息系统传染病报告信息管理系统2011-2020年北京市手足口病报告病例以及北京市16个区（县）的29家哨点医院的手足口病病原学监测。采用描述性流行病学方法分析北京市≥6岁人群手足口病病例的三间分布以及病原学构成和变化。 结果： 2011-2020年，北京市≥6岁人群累计报告手足口病38 183例，其中重症46例（占0.12%），年均报告发病率19.04/10万，男女性别比为1.37∶1（22 064∶16 119），≥6岁人群手足口病构成比由2011年的7.56%（2 606/34 488）增加至2020年的24.54%（546/2 225）。顺义区、延庆区和通州区≥6岁人群手足口病平均发病率较高。哨点监测肠道病毒阳性率为66.78%（1 976/2 959），2014年肠道病毒A组71型（EV-A71）构成比为45.29%（101/223），2020年无检测出EV-A71阳性，柯萨奇病毒A组6型（CV-A6）构成比从2016年的15.11%（34/225）提高到2020年的81.08%（60/74）。 结论： 2011-2020年北京市≥6岁人群手足口病患者构成比逐年升高，EV-A71阳性构成基本呈下降趋势。2016年以来，CV-A6已逐渐成为优势毒株。应重视≥6岁人群手足口病疫情以及病原学动态变化。.