This week (17 to 20 February), the virtual annual meeting of the American Association for the Advancement of Science (AAAS, the publisher of Science) will address the challenges of building the public's trust and understanding of science by illuminating both great science and innovative initiatives in advocacy, education, and policy. The theme, "Empower with Evidence," speaks to the critical importance of decision-making, policy-making, and interventions that are grounded in knowledge and facts, not opinions-or worse, misinformation.