Hepatocytic Apoptosis and Immune Dysfunction in Decompensation of Alcoholic Liver Cirrhosis with Different Grades of Acute-on-Chronic Liver Failure

A S Rodina; M E Shubina; I V Kurbatova; L V Topchieva; O P Dudanova

doi:10.1007/s10517-022-05404-7

Hepatocytic Apoptosis and Immune Dysfunction in Decompensation of Alcoholic Liver Cirrhosis with Different Grades of Acute-on-Chronic Liver Failure

Bull Exp Biol Med. 2022 Feb;172(4):410-414. doi: 10.1007/s10517-022-05404-7. Epub 2022 Feb 17.

Authors

A S Rodina¹, M E Shubina¹, I V Kurbatova², L V Topchieva², O P Dudanova³

Affiliations

¹ Department of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
² Laboratory for Genetics, Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia.
³ Department of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia. odudanova@gmail.com.

PMID: 35175469
DOI: 10.1007/s10517-022-05404-7

Abstract

Acute-on-chronic liver failure (ACLF) of varying grades was assessed in 110 patients with alcoholic liver cirrhosis using the on-line CLIF-C ACLF Calculator ( www.efclif.com/scientific-activity/score-calculators/clif-c-aclf ); fragments of cytokeratin-18, TNFα, IL-1β, IL-4, IL-6, and IL-8 were also assayed. As ACLF progressed from grade 0 to grade 3, the levels of cytokeratin-18 fragments, IL-6, and IL-8 significantly increased, while IL-4 decreased. TNFα peaked in ACLF grade 1, but decreased in grades 2 and 3. IL-1β did not depend on the ACLF grade. Thus, hepatic damage and immune dysfunction are implicated in the progression of ACLF.

Keywords: acute on chronic liver failure; alcoholic liver cirrhosis; apoptosis; immune dysfunction.

MeSH terms

Acute-On-Chronic Liver Failure*
Apoptosis
Humans
Liver Cirrhosis
Liver Cirrhosis, Alcoholic