Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review

Abstract

Introduction: Chondral defects of the knee are common and their treatment is challenging.

Source of data: PubMed, Google scholar, Embase and Scopus databases.

Areas of agreement: Both autologous matrix-induced chondrogenesis (AMIC) and membrane-induced autologous chondrocyte implantation (mACI) have been used to manage chondral defects of the knee.

Areas of controversy: It is debated whether AMIC and mACI provide equivalent outcomes for the management of chondral defects in the knee at midterm follow-up. Despite the large number of clinical studies, the optimal treatment is still controversial.

Growing points: To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.

Areas timely for developing research: AMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.

Keywords: AMIC; Knee; chondral defect; mACI.