Interleukins and Ischemic Stroke

Front Immunol. 2022 Jan 31:13:828447. doi: 10.3389/fimmu.2022.828447. eCollection 2022.

Abstract

Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information transmission, activation and regulation of immune cells, mediating the activation, multiplication and differentiation of T and B cells and in the inflammatory reaction. Crosstalk between different ILs in different immune cells also impact the outcome of ischemic stroke. This overview is aimed to roughly discuss the multiple roles of ILs after ischemic stroke. The roles of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-16, IL-17, IL-18, IL-19, IL-21, IL-22, IL-23, IL-32, IL-33, IL-34, IL-37, and IL-38 in ischemic stroke were discussed in this review.

Keywords: cytokines; inflammation; interleukins; ischemic stroke; neuro-immune.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / pathology*
  • Humans
  • Inflammation / metabolism
  • Interleukins / genetics*
  • Interleukins / metabolism
  • Ischemic Stroke / genetics*
  • Ischemic Stroke / metabolism
  • Ischemic Stroke / pathology

Substances

  • Interleukins